Economic evaluation alongside randomised controlled trials: design, conduct, analysis, and reporting Collecting economic data at the same time as evidence of effectiveness maximises the information available for analysis but requires proper consideration at the design stage
نویسنده
چکیده
Economic evaluation involves the comparative analysis of the costs and consequences of alternative programmes or interventions. It has increasingly been used to inform decision making about healthcare in the United Kingdom and other industrialised nations. Randomised controlled trials are commonly used as a vehicle for economic evaluations. Indeed, many funders, such as the UK National Institute for Health Research Health Technology Assessment Programme, routinely request that assessments of cost effectiveness are incorporated in the design of randomised trials. This article outlines some of the key issues concerning the design, conduct, analysis, and reporting of economic evaluations based on trials with individual patient data. Economic evaluations that synthesise data from disparate sources using decision analytical models (typically using summary rather than individual patient data) are discussed in an accompanying article. What are the objectives of economic evaluation?
منابع مشابه
Economic evaluation using decision analytical modelling: design, conduct, analysis, and reporting.
Economic evaluations are increasingly conducted alongside randomised controlled trials, providing researchers with individual patient data to estimate cost effectiveness.However, randomised trials do not always provide a sufficient basis for economic evaluations used to inform regulatory and reimbursement decisions. For example, a single trial might not compare all the available options, provid...
متن کاملEvaluation of Clinical Trials
In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...
متن کاملDesign and analysis issues for economic analysis alongside clinical trials.
INTRODUCTION Clinical trials can offer a valuable and efficient opportunity to collect the health resource use and outcomes data for economic evaluation. However, economic and clinical studies differ fundamentally in the question they seek to answer. OBJECTIVE The design and analysis of trial-based cost-effectiveness studies require special consideration, which are reviewed in this article. ...
متن کاملChallenges in the Design, Conduct, Analysis, and Reporting of Randomized Clinical Trial Studies in Iran: A Qualitative Study
Background and Objectives: Randomized clinical trials are the gold standard for evaluating the effectiveness and safety of medical interventions. Some unpredictable challenges may affect the results of these studies. Therefore, the aim of this study was to identify the challenges of clinical trial studies in different stages including design, conduct, analysis, and reporting. Methods: This ...
متن کاملدرماتولوژی مبتنی بر شواهد: گزارش درست مقایسهی پیامدها در کارآزماییهای بالینی
According to evidence-based medicine, randomized controlled clinical trials are a group of research designs which provides the highest level of clinical evidence, particularly regarding therapeutic or preventive interventions. Considering the dramatic increase in the number of published clinical trials in medical journals, the readership need to have knowledge about the problems that may occur ...
متن کامل